If you have ever heard of Cardarine, you may know that it’s also known by the name of GW-501516. For some of us who are aware of the professional names of SARMs, GW-501516 is also called as Endurobol.

The SARM (Selective Androgen Receptor Modulator) was synthesized in 1990 by GlaxoSmithKline (GSK) and Ligand Pharmaceuticals as a safe alternative for metabolic and heart conditions.


A lot of professional label Cardarine as a SARM and there has been a lot of confusion about that fact. It is actually a PPAR-δ receptor agonist. It was initially launched in the market to phenomenally reduce the predisposition to atherosclerosis, which is a dyslipidemia disorder.

I bring you some important ‘must-know’ facts about Endurobol after analyzing the SARM rigorously. Here is your complete professional guide for Cardarine.

How Does Cardarine (GW-501516) Work?

I mentioned earlier that Cardarine is a PPAR-δ receptor agonist that shouldn’t be confused with SARMs, but they have a similar mechanism to those of SARMS.

This compound is personally the most baffling compound that I have come across my professional career. What’s amazing about Cardarine is that it allows the regulation of fatty acid metabolism by the body.

These facts have been backed up by various studies, one of which is shown below to increase the endurance by nearly 32% after 3 weeks of regular dosage.

Cardarine in Works

The mechanism can be better understood by dividing it into three parts.

1. PPAR-δ Agonist

The PPAR-δ (Peroxisome Proliferator-Activated Receptor-delta) agonist binds with receptors and activates the androgen receptors of muscles. The heightened activities of these receptors increase the amino acids and glucose uptake in the skeletal muscles and increase insulin sensitivity in return.

2. Glucose

The GLUT-4 receptors lie on the surface of the membrane that has a high sensitivity to the anabolic hormone insulin. These receptors allow the entry of glucose into the cell.

Muscles have an increased growth due to an increase in amino acids leading to more synthesis of proteins. Nothing we eat is stored as fats or carbohydrates instead lean muscles are promoted. At the end of the process, the levels of ABCA1 and cholesterol transporter are also increased.

3. LDL and HDL

The good cholesterol (HDL) from the periphery is transported to the liver, and the antagonist to HDL, bad cholesterol (LDL) is decreased to improve metabolism.

The body gets rid of excess fat, cholesterol, triglycerides, & glucose, and the liver function improves significantly after consuming Cardarine.

What are the Benefits of Cardarine (GW-501516)?

Apart from the point of view of sports, Cardarine has some other major health benefits.

Body Builder after Consuming Cardarine

Improved Blood Vessels and Heart Functions

By preventing the oxidative damage to blood vessels and preventing the plaque build-up in the arteries, Cardarine protects and relaxes the blood vessels by increasing nitric oxide.

When taken in lower doses, Endurobol lowers the tissue damage and inflammation of the arteries that lowers the risk of heart diseases. It also promotes the growth of new blood vessels in the heart cells by increasing VEGF, which is also beneficial for people with heart diseases.

Resolves Obesity

In a double-blinded randomized controlled trial on 6 overweight volunteers, Cardarine showed to counteract metabolic syndrome. This happens due to the rapid carnitine in muscles and increased fat burning of inflammatory cytokines.

The liver fat was reduced by 20%, blood fats by 30%, and insulin by 11% when 2.5mg of Cardarine was used daily for two weeks. Obesity-induced insulin resistance and chronic inflammation are prevented through PPAR-δ activation in fat tissues.

Augments Quick Fat Loss

Another experiment on 13 men with belly fat (bad cholesterol profile) showed that Cardarine decreases VLDL proteins, fatty acids, and triglycerides. The liver is forced to get rid of these VLDL proteins by a dose of 2.5 mg/day for 6 weeks, that results in loss of fats. For patients with high APOB, 5-10 mg/day dosage was given for 12 weeks.

For inactive people, fats are used as a source of energy that applies them to muscle cells. A daily dosage of 10mg/day for two weeks activates carnitine genes (CPT1 and ABCA1) that activates quick fat burning.

Fat Loss

Reduces Liver Damage

The crucial organ responsible for releasing, burning, and storing fats in the body is targeted by Cardarine. Through PPAR activation, blood sugar is reduced by forcing the liver to switch to fatty acids as a source of energy rather than glucose.

Reduced IL-6 leads to prevention of insulin resistance in liver cells. Cardarine prevented high-fructose diet from damaging the liver in some cases, but in some rare cases, it caused fibrosis in the liver.

Endurance, Stamina and Muscle Increase

Physical performance and development of muscle fibers are aided by Cardarine through activation of PPAR delta. It is considered as an ultimate endurance enhancer due to its ability to increase endurance by 200%.

For endurance athletes and professional sportsperson, Cardarine is known to allow rapid recovery and elevate the mood. Endurobol has made it possible for athletes to train harder for longer durations with a minimum resting or recovery period.


A 10mg per day dosage of Cardarine for 4 weeks resulted in reducing MCP-1 activity (responsible for kidney diseases) that decreased kidney inflammation. Tests on mice have confirmed the reduced activities of MCP-1 genes that reduce kidney diseases.


Cardarine has been clinically proven from animal studies to prevent the brain from suffering nerve-vessel damage and oxidative stress. In fact, PPAR activators are known to develop the nerve cells and maintain normal blood flow to the brain.

Cardarine (GW-501516) Side-Effects

When I got down to research for the potential side-effects of Cardarine, I was not able to find any data or sufficient lab results that would point out towards the side effects of Cardamine. The data available on the internet didn’t seem constant or relevant at the time.

Cardarine currently has no major side-effects yet, but that may not be the case in the future. If you are willing to be positive and consume Endurobol, then do follow the dosage guidelines that I will give you later on in this article.

Liver Damage

Yes, I know that I had earlier mentioned that Cardarine prevents damaging of the liver, and I am not contradicting that. For people with liver diseases, Cardarine works in the exact opposite way by escalating liver cell damage.

Hence, for people with very weak livers or previous history of liver damage, Cardarine has the side-effect to worsen the damage to the liver. This was confirmed from a test done on mice who had previous liver damage.

Unsafe During Pregnancy

Another result of studies done on animals (particularly female mammals) showed that an extended dosage of GW-501516 inhibits fetal development. It was after this revolutionizing test that it was declared unsafe for pregnant women.

Cardarine Could Possibly Be Carcinogenic

Another gray area surrounding Endurobol is that it is rumored to cause cancer in humans as shown by some tests on rats.

What’s controversial about this test is that rats were given a higher dosage of 54.9 mg, 219.6 mg, and 439.2 mg daily for two years. The smallest dose of 55 mg given to rats is about 5 times the normal dosage given to humans. Yes, overdosing Endurobol may cause cancer, but as long as the right dosage is taken, I don’t see any chance of that happening.

Cardarine (GW-501516) Cycle

1. Dosage

Solo Use

Only if you’re using Cardarine as a stand-alone product, I’d recommend 10 to 20 mg taken daily 2-3 hours prior to exercise for a duration of 4-5 weeks.

During Post-Cycle

Due to its non-hormonal nature, Cardarine can be used during post-cycle therapy to prevent fat rebound. A dosage of 10-20 mg daily for the entire duration of the post-cycle therapy.

During A Steroid Cycle

When using Cardarine with Anabolic steroids, stack 20mg of GW-501516 every day to counteract the endurance destroying nature of these steroids.

During A SARMs Cycle

When using Endurobol as a base of SARMs cycle, it would be wise to follow a normal dosage of 10-20 mg daily for 12 weeks.

2. Duration

It is considered safe to use Cardarine in humans for a duration of up to 6 months. However, I would recommend to respect the drug and take the dosage for a duration of 12 weeks with 4 to 6 weeks of cycling off. After the cycling off period, you can use Cardarine for another 12 weeks and so on.

3. Half-Life

A staggering half-life of 24 hours allows you to have a ‘once-daily’ dosage of the required amount.

Cardarine (GW-501516) Before And After Results

The interesting fact about Endurobol is that you can work-out with more intensity and for longer durations as your stamina, endurance, and heart are functioning better. Cardarine can be used for both, during bulking or cutting as it shows some amazing results either way.

Let’s look at the image of a happy consumer who was able to transform his body completely after a couple of 12-week program of Cardarine with 4 weeks of cycle off period in between. He followed a GW-501516 dosage of 20 mg/day with regular exercise. He started with 14% body fat and in 6 weeks, was able to bring it down to just 5%.

Cardarine has proven to help in fat-cutting while maintaining muscle mass and giving you those intense cardio-sessions.

Cardarine Before and After

Where can you buy Cardarine (GW-501516) from?

When looking to purchase Cardarine, genuinity of the seller and the compound is of prime importance. Focus on buying from a trusted and legitimate source as the compound is still under research and may not have a lot of authentic suppliers.

It’s needless to say that the market is flooded with products that give a ‘placebo-effect’ or work apparently but have high adulterants that cause serious health concerns. Known online SARMS stores and quality dealers can be easily found over the internet.


I can guarantee that GW-501516 is one of the most world-renowned compounds in the bodybuilding community as it offered tremendous results. This single compound gives you drastic fat loss, increase energy, and boost endurance.

However, I would recommend buying the compound from a legitimate vendor that has a license for authenticity. You do not want a Cardarine product that has temporary placebo-effect. Lastly, remember to follow the dosage for the recommended duration and try to keep the cycles short.

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Matt Williamson
My name is Matt - fitness freak by choice. I intensively study and write about nutrition and health related topics. After reading and researching intensively on human health, I aspire to proliferate the wisdom that I acquired in a simple way.